iPSC Line Catalog

Alzheimer's Disease iPSC Lines

Genotype iPSC Line Name APOE Genotype

Sex and Age at Tissue Collection

Status and Available Materials Additional Associated Lines and Details Original Source Approvals Necessary
 fAD APPV717I HVRDi001-A and HVRDi002-A Both E3/E3
  • 1 Female (33)
  • 1 Male (57)
  • Available
    • iPSCs
    • NGR iPSCs
    • Day 4 NGR-derived neurons
  • 2 subjects, 2 clones each subject
  • isogenic control to 1 subject
None (with MTA in place)
fAD APP-E693∆ APP1E211 E3/E3
  • Female (59)
  • Age of onset - 35
  • Available
    • iPSCs
N/A Labs will need to be added to MTA
fAD PSEN1 H163R F11430.3 and F12442.4
  • Affected: E3/E4
  • Unaffected: E3/E3
  • Affected: Male (41)
  • Unaffected: Female (30)
  • Available
    • iPSCs
    • NGR iPSCs

 

unaffected family member control

DIAN, Wash U Labs will need to be added to MTA
fAD PSEN1 A79V F12424.4 and F12436.2
  • Affected: E3/E4
  • Unaffected: E3/E3
  • Affected: Male (54)
  • Unaffected: Male (31)
  • Available
    • iPSCs
    • NGR iPSCs

unaffected family member control

DIAN, Wash U Labs will need to be added to MTA
fAD PSEN1 G217R F12434.1 and F12445.5
  • Affected: E2/E4
  • Unaffected: E3/E4
  • Affected: Male (35)
  • Unaffected: Female (55)
  • Available
    • iPSCs
    • NGR iPSCs

unaffected family member control

DIAN, Wash U Labs will need to be added to MTA
fAD PSEN2 N141I F12448.9

E3/E3

Affected: Female (31)

  • Available
    • iPSCs
    • NGR iPSCs
  DIAN, Wash U Labs will need to be added to MTA
MAPT P301L TAU P301L    
  • Available
    • iPSCs
    • NGR iPSCs
    • Day 4 neurons
  • multiple clones
  • isogenic control 
Karch Lab, Wash U Include Dr. Karch in publication
MAPT P301S TAU P301S    
  • Available
    • iPSCs
    • NGR iPSCs
    • Day 4 neurons

mutation induced from Tau P301L

Karch Lab, Wash U Include Dr. Karch in publication
MAPT KO C1285 clone 45 E3/E3 Male (37) 
  • Available (1 clone)
    • iPSCs
    • NGR iPSCs 
  • 2 clones
  • Parent line (no MAPT KO) F11350.1
  • Kao Lab, UCSF
  • NeuralCell - Tau Consortium
Include Dr. Kao in publication
MAPT V337M GIH 6   Female (66)
  • Available (1 clone)
    • iPSCs
  • 2 clones (C3, C4)
  • asymptomatic
  • isogenic control (GIH6C1∆1E11)
NeuralCell - Tau Consortium None (with MTA in place)
MAPT V337M GIH 7   Female (37) In house, needs to be expanded
  • 3 clones (C1, C2, C3)
  • symptomatic
  • isogenic control (GIH7C2∆2B12)
NeuralCell - Tau Consortium None (with MTA in place)
MAPT IVS10+16 GIH 36   Male (31)
  • Available (1 clone)​​​​​​​
    • iPSCs
  • 2 clones (C1, C2)
  • asymptomatic
NeuralCell - Tau Consortium None (with MTA in place)
MAPT IVS10+16 GIH 104   Male (57) Mutant in house, needs to be expanded; isogenic arriving in future
  • 3 clones (C1, C2, C3)
  • symptomatic
NeuralCell - Tau Consortium None (with MTA in place)
APOE multiple isoform combos
  • BIONi037-A
  • BIONi037-A-1
  • BIONi037-A-2
  • BIONi037-A-4
parent line E3/E3

Female (77)

Shipping from EBiSC in future EBiSC None (with MTA in place)
APOE multiple isoform combos
  • iPS16
  • iPS26 
  • iPS36
parent line E4/E4 Male (31)
  • Available
    • iPSCs
    • NGR iPSCs
Alstem None (with MTA in place)

 

Parkinson's Disease iPSC Lines

Genotype iPSC Line Name Sex and Age at Tissue Collection Status and Available Materials Additional Associated Lines and Details Original Source Approvals Necessary
SNCA triplication EDi001-A Female (55)
  • Available
    • iPSCs
    • NGR iPSCs
EBiSC None (with MTA in place)
SNCA A53T ND50085 Female (51)
  • Available
    • iPSCs
    • NGR iPSCs
    • D4 NGR-derived neurons
  • mutation line went through editing process, but no correction made
  • isogenic control (ND50086)
NINDS Some labs may need to be added to MTA
SNCA A53T WIBR-hiPS-SNCA A53T Female In house, needs to be expanded
  • 2 clones
  • isogenic control (WIBR-hiPS-SNCA A53T-Corr)
    • 2 clones
Jaenisch Lab Labs without MTA will need to establish own MTA
LRRK2 G2019S

ND50051

Male (52)
  • Available
    • iPSCs
    • NGR iPSCs
  • 1 additional clone (ND50052)
NINDS Some labs may need to be added to MTA
LRRK2 G2019S ND35367 Male (79)
  • Available
    • iPSCs
    • NGR iPSCs
  NINDS Some labs may need to be added to MTA
LRRK2 G2019S UOXFi007-A
  • Female (70-74)
  • Available
    • iPSCs
    • NGR iPSCs
  EBiSC None (with MTA in place)
LRRK2 R1441C ND34393
  • Male (58)
  • Affected twin sister (58)
  • Available
    • iPSCs
  • 2 clones (other clone is ND34394)
  • affected family member (twin sister) (ND35371)
NINDS Some labs may need to be added to MTA
LRRK2 R1441C ND35371
  • Female (58)
  • Affected twin brother (58)
  • Available
    • iPSCs
  • affected family member (twin brother) (ND34393 and ND34394)
NINDS Some labs may need to be added to MTA
PARK2 1-BP DEL, 255A EX3-4DEL ND38477 Male (50)
  • Available
    • iPSCs
    • NGR iPSCs
  NINDS Some labs may need to be added to MTA
GBA N370S/84GG insertion GM00852 Male (20)
  • Available
    • iPSCs
  Some labs may need to be added to MTA