April 9, 2018

In Nature Medicine, Wang et al. model AD using ApoE3 and ApoE4 iPSCs here. Summary: Efforts to develop drugs for Alzheimer’s disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells that expressed apolipoprotein E4 (ApoE4), a variant of the APOE gene product and the major…