iPSC NeuroHub

iPSC Line Catalog

Alzheimer’s Disease iPSC Lines

GenotypeiPSC Line NameAPOE GenotypeSex and Age at Tissue CollectionStatus and Available MaterialsAdditional Associated Lines and DetailsOriginal SourceApprovals Necessary
 fAD APPV717IHVRDi001-A and HVRDi002-ABoth E3/E31 Female (33)1 Male (57)AvailableiPSCsNGR iPSCsDay 4 NGR-derived neurons2 subjects, 2 clones each subjectisogenic control to 1 subjectYoung-Pearse Lab, BWHpublicationNone (with MTA in place)
fAD APP-E693∆APP1E211E3/E3Female (59)Age of onset – 35AvailableiPSCsN/AInoue Lab, Kyoto UniversitypublicationLabs will need to establish their own MTA.
fAD PSEN1 H163RF11430.3 and F12442.4Affected: E3/E4Unaffected: E3/E3 AvailableiPSCsNGR iPSCs unaffected family member controlDIAN, Wash ULabs will need to establish their own MTA.
fAD PSEN1 A79VF12424.4 and F12436.2Affected: E3/E4Unaffected: E3/E3 AvailableiPSCsNGR iPSCsunaffected family member controlDIAN, Wash ULabs will need to establish their own MTA.
fAD PSEN1 G217RF12434.1 and F12445.5Affected: E2/E4Unaffected: E3/E4 AvailableiPSCsNGR iPSCsunaffected family member controlDIAN, Wash ULabs will need to establish their own MTA.
fAD PSEN2 N141IF12448.9E3/E3 AvailableiPSCsNGR iPSCs DIAN, Wash ULabs will need to establish their own MTA.
MAPT P301LTAU P301L  AvailableiPSCsNGR iPSCsDay 4 neuronsmultiple clonesisogenic control Karch Lab, Wash UInclude Dr. Karch in publication
MAPT P301STAU P301S  AvailableiPSCsNGR iPSCsDay 4 neuronsmutation induced from Tau P301LKarch Lab, Wash UInclude Dr. Karch in publication
MAPT KOC1285 clone 45E3/E3Male (37) Available (1 clone)iPSCsNGR iPSCs 2 clonesParent line (no MAPT KO) F11350.1Kao Lab, UCSFNeuralCell – Tau ConsortiumInclude Dr. Kao in publication
MAPT V337MGIH 6 Female (66)Available (1 clone)iPSCs2 clones (C3, C4)asymptomaticisogenic control (GIH6C1∆1E11)NeuralCell – Tau ConsortiumNone (with MTA in place)
MAPT V337MGIH 7 Female (37)In house, needs to be expanded3 clones (C1, C2, C3)symptomaticisogenic control (GIH7C2∆2B12)NeuralCell – Tau ConsortiumNone (with MTA in place)
MAPT IVS10+16GIH 36 Male (31)Available (1 clone)iPSCs2 clones (C1, C2)asymptomaticNeuralCell – Tau ConsortiumNone (with MTA in place)
MAPT IVS10+16GIH 104 Male (57)Mutant in house, needs to be expanded; isogenic arriving in future3 clones (C1, C2, C3)symptomaticNeuralCell – Tau ConsortiumNone (with MTA in place)
        
APOE multiple isoform combosiPS16iPS26 iPS36parent line E4/E4Male (31)AvailableiPSCsNGR iPSCsAPOE E3/E3APOE E4/E4APOE KOAll isogenic to E4/E4AlstemNone (with MTA in place)

Parkinson’s Disease iPSC Lines

GenotypeiPSC Line NameSex and Age at Tissue CollectionStatus and Available MaterialsAdditional Associated Lines and DetailsOriginal SourceApprovals Necessary
SNCA triplicationEDi001-AFemale (55)AvailableiPSCsNGR iPSCsisogenic control (EDi001-A-4)EBiSCNone (with MTA in place)
SNCA A53TND50085Female (51)AvailableiPSCsNGR iPSCsD4 NGR-derived neuronsmutation line went through editing process, but no correction madeisogenic control (ND50086)NINDSLabs will need to establish their own MTA.
SNCA A53TWIBR-hiPS-SNCA A53TFemaleIn house, needs to be expanded2 clonesisogenic control (WIBR-hiPS-SNCA A53T-Corr)2 clonesJaenisch LabLabs will need to establish their own MTA.
LRRK2 G2019SND50051Male (52)AvailableiPSCsNGR iPSCs1 additional clone (ND50052)NINDSLabs will need to establish their own MTA.
LRRK2 G2019SND35367Male (79)AvailableiPSCsNGR iPSCs NINDSLabs will need to establish their own MTA.
LRRK2 G2019SUOXFi007-AFemale (70-74)AvailableiPSCsNGR iPSCs EBiSCNone (with MTA in place)
LRRK2 R1441CND34393Male (58)Affected twin sister (58)AvailableiPSCs2 clones (other clone is ND34394)affected family member (twin sister) (ND35371)NINDSLabs will need to establish their own MTA.
LRRK2 R1441CND35371Female (58)Affected twin brother (58)AvailableiPSCsaffected family member (twin brother) (ND34393 and ND34394)NINDSLabs will need to establish their own MTA.
PARK2 1-BP DEL, 255A EX3-4DELND38477Male (50)AvailableiPSCsNGR iPSCs NINDSLabs will need to establish their own MTA.
GBA N370S/84GG insertionGM00852Male (20)AvailableiPSCs Krainc Lab, Northwestern U.publicationLabs will need to establish their own MTA.

Request an iPSC Line

If you would like to request a vial of iPSCs from the current NeuroHub repository, email Christina with the following details: 

  • Your name/PI
  • Cell line name
  • Date you would like to receive/thaw the cells
  • Indicate if you need assistance with thawing cells  

If you would like to acquire a new iPSC line to the NeuroHub, email Christina with the following details: 

  • Cell line name
  • Vendor/Institution
  • Catalog number
  • Any other identifiying information