Alzheimer’s Disease iPSC Lines
Genotype | iPSC Line Name | APOE Genotype | Sex and Age at Tissue Collection | Status and Available Materials | Additional Associated Lines and Details | Original Source | Approvals Necessary |
---|---|---|---|---|---|---|---|
fAD APPV717I | HVRDi001-A and HVRDi002-A | Both E3/E3 | 1 Female (33)1 Male (57) | AvailableiPSCsNGR iPSCsDay 4 NGR-derived neurons | 2 subjects, 2 clones each subjectisogenic control to 1 subject | Young-Pearse Lab, BWHpublication | None (with MTA in place) |
fAD APP-E693∆ | APP1E211 | E3/E3 | Female (59)Age of onset – 35 | AvailableiPSCs | N/A | Inoue Lab, Kyoto Universitypublication | Labs will need to establish their own MTA. |
fAD PSEN1 H163R | F11430.3 and F12442.4 | Affected: E3/E4Unaffected: E3/E3 | AvailableiPSCsNGR iPSCs | unaffected family member control | DIAN, Wash U | Labs will need to establish their own MTA. | |
fAD PSEN1 A79V | F12424.4 and F12436.2 | Affected: E3/E4Unaffected: E3/E3 | AvailableiPSCsNGR iPSCs | unaffected family member control | DIAN, Wash U | Labs will need to establish their own MTA. | |
fAD PSEN1 G217R | F12434.1 and F12445.5 | Affected: E2/E4Unaffected: E3/E4 | AvailableiPSCsNGR iPSCs | unaffected family member control | DIAN, Wash U | Labs will need to establish their own MTA. | |
fAD PSEN2 N141I | F12448.9 | E3/E3 | AvailableiPSCsNGR iPSCs | DIAN, Wash U | Labs will need to establish their own MTA. | ||
MAPT P301L | TAU P301L | AvailableiPSCsNGR iPSCsDay 4 neurons | multiple clonesisogenic control | Karch Lab, Wash U | Include Dr. Karch in publication | ||
MAPT P301S | TAU P301S | AvailableiPSCsNGR iPSCsDay 4 neurons | mutation induced from Tau P301L | Karch Lab, Wash U | Include Dr. Karch in publication | ||
MAPT KO | C1285 clone 45 | E3/E3 | Male (37) | Available (1 clone)iPSCsNGR iPSCs | 2 clonesParent line (no MAPT KO) F11350.1 | Kao Lab, UCSFNeuralCell – Tau Consortium | Include Dr. Kao in publication |
MAPT V337M | GIH 6 | Female (66) | Available (1 clone)iPSCs | 2 clones (C3, C4)asymptomaticisogenic control (GIH6C1∆1E11) | NeuralCell – Tau Consortium | None (with MTA in place) | |
MAPT V337M | GIH 7 | Female (37) | In house, needs to be expanded | 3 clones (C1, C2, C3)symptomaticisogenic control (GIH7C2∆2B12) | NeuralCell – Tau Consortium | None (with MTA in place) | |
MAPT IVS10+16 | GIH 36 | Male (31) | Available (1 clone)iPSCs | 2 clones (C1, C2)asymptomatic | NeuralCell – Tau Consortium | None (with MTA in place) | |
MAPT IVS10+16 | GIH 104 | Male (57) | Mutant in house, needs to be expanded; isogenic arriving in future | 3 clones (C1, C2, C3)symptomatic | NeuralCell – Tau Consortium | None (with MTA in place) | |
APOE multiple isoform combos | iPS16iPS26 iPS36 | parent line E4/E4 | Male (31) | AvailableiPSCsNGR iPSCs | APOE E3/E3APOE E4/E4APOE KOAll isogenic to E4/E4 | Alstem | None (with MTA in place) |
Parkinson’s Disease iPSC Lines
Genotype | iPSC Line Name | Sex and Age at Tissue Collection | Status and Available Materials | Additional Associated Lines and Details | Original Source | Approvals Necessary |
---|---|---|---|---|---|---|
SNCA triplication | EDi001-A | Female (55) | AvailableiPSCsNGR iPSCs | isogenic control (EDi001-A-4) | EBiSC | None (with MTA in place) |
SNCA A53T | ND50085 | Female (51) | AvailableiPSCsNGR iPSCsD4 NGR-derived neurons | mutation line went through editing process, but no correction madeisogenic control (ND50086) | NINDS | Labs will need to establish their own MTA. |
SNCA A53T | WIBR-hiPS-SNCA A53T | Female | In house, needs to be expanded | 2 clonesisogenic control (WIBR-hiPS-SNCA A53T-Corr)2 clones | Jaenisch Lab | Labs will need to establish their own MTA. |
LRRK2 G2019S | ND50051 | Male (52) | AvailableiPSCsNGR iPSCs | 1 additional clone (ND50052) | NINDS | Labs will need to establish their own MTA. |
LRRK2 G2019S | ND35367 | Male (79) | AvailableiPSCsNGR iPSCs | NINDS | Labs will need to establish their own MTA. | |
LRRK2 G2019S | UOXFi007-A | Female (70-74) | AvailableiPSCsNGR iPSCs | EBiSC | None (with MTA in place) | |
LRRK2 R1441C | ND34393 | Male (58)Affected twin sister (58) | AvailableiPSCs | 2 clones (other clone is ND34394)affected family member (twin sister) (ND35371) | NINDS | Labs will need to establish their own MTA. |
LRRK2 R1441C | ND35371 | Female (58)Affected twin brother (58) | AvailableiPSCs | affected family member (twin brother) (ND34393 and ND34394) | NINDS | Labs will need to establish their own MTA. |
PARK2 1-BP DEL, 255A EX3-4DEL | ND38477 | Male (50) | AvailableiPSCsNGR iPSCs | NINDS | Labs will need to establish their own MTA. | |
GBA N370S/84GG insertion | GM00852 | Male (20) | AvailableiPSCs | Krainc Lab, Northwestern U.publication | Labs will need to establish their own MTA. |
Request an iPSC Line
If you would like to request a vial of iPSCs from the current NeuroHub repository, email Christina with the following details:
- Your name/PI
- Cell line name
- Date you would like to receive/thaw the cells
- Indicate if you need assistance with thawing cells
If you would like to acquire a new iPSC line to the NeuroHub, email Christina with the following details:
- Cell line name
- Vendor/Institution
- Catalog number
- Any other identifiying information