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Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-b-Dependent Neuroectodermal Commitment
April 3, 2020 A 2019 paper from Markouli and others shows that a gain of genomic abberration 20q11.21 in iPSCs significantly impairs TGF-b-Dependent Neuroectodermal Commitment.
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Make your own cheap, weekend-free media!
March 26, 2020 Kuo et al published a paper in Stem Cell Reports outlining how labs can create their own weekend-free media for about 3% of the cost of commerical medias. The […]
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Prolonged ROCKi treatment can decrease pluripotency of iPSCs
March 26, 2020 Närvä et al published a paper in Stem Cell Reports in 2017 showing the importance of focal adhesions in iPSC colonies. • Human pluripotent colonies have exceptional actin structure […]
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COVID-19 abolishes pluripotency in iPSCs
March 26, 2020 This Zebin et al paper was published in SSRN showing that the Coronavirus strain causing the current COVID-19 pandemic, SARS-CoV-2, can abolish human induced pluripotent stem cell pluripotency. Mutant cells […]
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iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates
February 26, 2020 Laperle et. al published a paper in Nature Medicine showing phorbol esters can reduce α-synuclein and PKCα levels in dopaminergic neurons, suggesting they may be therapeutic candidates for Parkinson’s disease […]
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Bioethicists and scientists publish opinion on guidelines toward iPSC-derived embryonic models
February 11, 2020 Hyun et al published a piece in Stem Cell Reports commenting on the possiblility and implications of using stem cells to create embryo-like models. They end the piece with […]
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Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
May 22, 2018 Nehme et al. published in Cell Reports an article detailing characterization of Ngn2-induced neurons. Summary: Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an approach to generate […]
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Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro
May 3, 2018 Sarkar et al. report here in Cell Stem Cell a new method for differentiating CA3 pyramidal neurons from iPSCs. Summary: Despite widespread interest in using human induced pluripotent stem […]
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An in vivo model of functional and vascularized human brain organoids
April 16, 2018 Mansour et al. publish about a new way to vascularize organoids by transplanting cerebral organoids into the cortex of an adult mouse. Summary: Differentiation of human pluripotent stem cells to small […]
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Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids
April 12, 2018 From the Young-Pearse lab, Lagomarsino and Srikanth et al. highlight the utility of modeling disease with a three-dimensional culture method, allowing for the study of developing cortical […]
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