March 19, 2018

In this Stem Cell Reports article Young et al. utilize iPSC-derived neurons to test a compond’s ability to modulate or stablize the retromer. This compound was found to reduce Abeta and phosphorylated tau in human neurons in both fAD and sporadic cell lines. Retomer stablization via the compound was able to reduce phosphorylated tau in an APP-dependent manner. These studies were…