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Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
April 9, 2018 In Nature Medicine, Wang et al. model AD using ApoE3 and ApoE4 iPSCs here. Summary: Efforts to develop drugs for Alzheimer’s disease (AD) have shown promise in animal […]
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Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
March 19, 2018 In Nature Medicine Shi et al. use human iPSCs to model amyotrophic lateral sclerosis. iPSCs were generated from patients with expanded repeats in C9ORF72 as well engineered iPSCs with one […]
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High-efficiency RNA-based reprogramming of human primary fibroblasts
March 19, 2018 In a paper published by Kogut et al. they describe using synthetic modified mRNAs encoding reprogramming factors and miRNA-367/302s to reprogram human primary fibroblasts into iPSCs. They were able to generate […]
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Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein
March 19, 2018 In this Stem Cell Reports article Young et al. utilize iPSC-derived neurons to test a compond’s ability to modulate or stablize the retromer. This compound was found to reduce […]
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Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons
March 13, 2018 In this article Liu and colleagues show that DS iPSC-derived GABA interneurons exhibit cellular deficits and decreased migration in vitro and in vivo.
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CRISPR/Cas9-Based Engineering of the Epigenome
March 12, 2018 This Protocol Review discusses CRISPR/Cas9 technology offers for investigating and manipulating the epigenome to facilitate further understanding of stem cell biology and engineering of stem cells for therapeutic applications.
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